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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
other: Expert statement based on skin irritation
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
Study period:
2002
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other: Expert Statement
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 404 "Acute Dermal Irritation /Corrosion"
Principles of method if other than guideline:
in the interest of animal welfare, the Swiss animal protection law does not allow to perform eye irritation study if the test item which has been in the skin irritation study exhibits an irritating potential.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
444-110-0
EC Name:
-
Cas Number:
16510-27-3
Molecular formula:
C11H14O
IUPAC Name:
1-(cyclopropylmethyl)-4-methoxybenzene
Details on test material:
Batch LDP200015

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
4 hours
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
3 animals of both sexes

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: Erythema
Basis:
animal: 64
Time point:
other: Mean value after 24, 48 nad 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
other: Erythema
Basis:
animal: 65
Time point:
other: Mean value after 24, 48 nad 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7 days
Irritation parameter:
other: Erythema
Basis:
animal: 66
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
other: Oedema
Basis:
animal: 64
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
other: Oedema
Basis:
animal: 65
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
other: Oedema
Basis:
animal:
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In absence of an experimental study and considering the skin irritation potential observed , Cyclopropyl Estragole is considered irritating to the eyes.