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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
444-110-0
EC Name:
-
Cas Number:
16510-27-3
Molecular formula:
C11H14O
IUPAC Name:
1-(cyclopropylmethyl)-4-methoxybenzene
Details on test material:
Batch Number LDP0200015
Purity 99.1%

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
3 animals of both sexes were used

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: 64
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
erythema score
Basis:
animal: 65
Time point:
other: mean value after 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 7 days
Irritation parameter:
erythema score
Basis:
animal: 66
Time point:
other: mean value after 24, 48 and 72 hours
Score:
2
Max. score:
2
Reversibility:
fully reversible within: 10 days
Irritation parameter:
edema score
Basis:
animal: 64
Time point:
other: mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
edema score
Basis:
animal: 65
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
edema score
Basis:
animal: 66
Time point:
other: Mean value after 24, 48 and 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Other effects:
Scalling was evident in all animals at 7- and 10-day readings and in one animal at the 14-day reading.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information according EU GHS criteria Criteria used for interpretation of results: EU
Conclusions:
Based upon the referred classification criteria (Commission Directive 2001/59/EC of August 06, 2001), Clyclopropyl Estragol is considered to be "R38-Irritating to skin".