Registration Dossier
Registration Dossier
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EC number: 414-490-2 | CAS number: 154212-59-6
Endpoint summary
Administrative data
Description of key information
Two key in-vivo studies have been completed, one for skin irritation and one for eye irritation. Both studies have been assigned a reliability score of 1.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Effects on eye irritation: corrosive
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin irritation study results: The presence of focal scab formation in three of six animals
suggests that this material has a potential to injure the skin that is difficult to evaluate. It is recommended that
H315: Skin Irritant 2 to be applied to this material.
Maximum duration of any effect:
Erythema: 14 days
Oedema: 14 days
Eye Irritation: Severe occular damage was observed including severe chemosis in all rabbits. Severe corneal opacity in three rabbits was observed with opaque corneas in two of the rabbits. This includes corneal ulceration in one of the rabbits on the final day of observation (day 21). Material is classified as H318: Eye damage 1.
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