Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 419-480-1 | CAS number: -
The test item did not induce toxic effects in the rat following oral or dermal administration of a single dose at a level of 2000 mg/kg.
Study conducted to recent EU & OECD test guidance in compliance with GLP.
Based on the present investigations, the test substance is regarded as relatively non-toxic and is not classified.
LD50 > 2000 mg/kg body weight.
Study conducted to recent EU test guidance 92/69/EEC part B3 and OECD test guideline 402 in compliance with GLP.
Based on the study the test substance is to be regarded as relatively non-toxic after acute dermal exposure. The test substance is not classified.
Testing on the above endpoints gave the following results:
Acute toxicity: Oral.
- LD50: >2000 mg/kg
Acute toxicity: Dermal.
Acute toxicity: Inhalation.
The test substance has a presumed very low vapour pressure and is a granular product, hence the potential for the generation of inhalable forms is low. In addition, production and use is done in a closed process without isolation of reaction products. The isolated product are dust free granules (non-dusty solid) which may be formulated into a liquid preparation of low volatility and the use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur. Dermal exposure is considered to be the appropriate route of exposure and has been assessed accordingly. No acute inhalation test was performed.
The following information is taken into account for any hazard / risk assessment:
Oral, inhalation and dermal acute toxicity are all considered.
Value used for CSA:
LD50 (oral): 2000 mg/kg bw
LD50 (dermal): 2000 mg/kg bw
The above studies have all been ranked reliability 1 according to the Klimish et al system. This ranking was deemed appropriate because the studies were conducted to GLP and in compliance with agreed protocols. ufficient dose ranges and numbers are detailed; hence it is appropriate for use based on reliability and animal welfare grounds.
The above results triggered no classification under the Dangerous Substance Directive (67/548/EEC) and the CLP Regulation (EC No 1272/2008). No classification for acute effects is therefore required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again