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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
February 01 to February 11 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to recognised test guideline in compliance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report Date:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
Deviations:
no
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Reaktiv Blau FC 75311

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
standard fat
Remarks:
HB307
Solubility:
< 0.003 mg/100 g solvent
Temp.:
20 °C
Remarks on result:
other: Measurements taken in 100 g fat at 37 °C
Test substance stable:
yes
Details on results:
See below

Any other information on results incl. tables

Details of the experiments:

 

Experiment

Pre-saturation

Stirring time

at 37 °C (h)

Mass ratio

Dissolved test substance/fat (mg/100 g)

No.

Stirring time (h)

Temperature (°C)

1

3.0

30

3

< 0.003

2

3.0

30

3

< 0.003

3

3.0

30

27

< 0.003

4

3.0

30

27

< 0.003

5

3.0

50

3

< 0.003

6

3.0

50

3

< 0.003

7

3.0

50

27

0.003

8

3.0

50

27

< 0.003

 

 Thus the ratio test substance per 100 g fat was calculated from the concentration of the lowest calibration standard (detection limit).

 

For evaluation of the result one has to take into account that the spectrometric measurements only include organic components showing absorption at the quantification wavelength.

Applicant's summary and conclusion

Conclusions:
The substance has been shown to be virtually insoluble in fat.
Executive summary:

The substance has been shown to be virtually insoluble in fat. This, coupled with the low partition coefficient value indicates that the substance is unlikely to be prone to bioaccumulation in its registered form.