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EC number: 937-697-4 | CAS number: -
(S)-1-(3-Methoxyphenyl)ethylamine was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test based on the method of Magnusson and Kligman. The test-substance concentrations for the main test were selected based on the results of the pretests. The intradermal induction was performed with a 0.5% test-substance preparation in peanut oil Ph.Eur. 5.5 or 0.5% test substance preparation in Freund’s complete adjuvant / 0.9% aqueous NaCl-solution (1 : 1) and the epicutaneous induction with a 1% test-substance preparation in peanut oil Ph.Eur. 5.5. For the challenge, a 0.5% test-substance preparation in peanut oil Ph.Eur. 5.5 was chosen. The study was performed using 1 control group and 1 test group. The intradermal induction was performed on day 0 and the epicutaneous induction on day 7. A challenge was carried out 14 days after the epicutaneous induction. The intradermal induction caused intense erythema and swelling at the injection sites of the test-substance preparations in all test group animals. After the epicutaneous induction, incrustation, partially open (caused by the intradermal induction) could be observed in addition to moderate and confluent erythema and swelling in all test group animals. After the challenge discrete or patchy to moderate and confluent erythema, swelling and scaling were observed in the test group animals.
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