Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other:
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
EC Number:
413-610-0
EC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
Cas Number:
124172-53-8
Molecular formula:
C26 H50 N4 O2
IUPAC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
not specified
Amount / concentration applied:
24 mg
Observation period (in vivo):
24, 48 and 72 h
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
2
Max. score:
2
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
2
Max. score:
2
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
1.7
Max. score:
2
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
2
Remarks on result:
other: Max. duration: 72 h
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
0.7
Max. score:
2
Remarks on result:
other: Max. duration: 72 h
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
1.7
Max. score:
2
Remarks on result:
other: Max. duration: 72 h
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
0.3
Max. score:
1
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 8 d
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 72 h
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 72 h
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 h
Score:
1
Max. score:
1
Remarks on result:
other: Max. duration: 72 h
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 15 days.
Other effects:
Contracted pupil, marginal cornea vascularisation, bloody secretion, damage of cornea substance, ulceration.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU