Registration Dossier
Registration Dossier
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EC number: 413-610-0 | CAS number: 124172-53-8 LICHTSCHUTZMITTEL 1736
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
- EC Number:
- 413-610-0
- EC Name:
- N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
- Cas Number:
- 124172-53-8
- Molecular formula:
- C26 H50 N4 O2
- IUPAC Name:
- N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- 0.5 % CMC formulation
- Duration of treatment / exposure:
- 16, 24 and 48 h for each dose
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
300 mg/kg
Basis:
no data
- Remarks:
- Doses / Concentrations:
600 mg/kg
Basis:
no data
- Remarks:
- Doses / Concentrations:
1200 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- 5
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: > 300 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Neither a clastogenic effect nor chromosome aberration was observed.
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