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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Link to relevant study record(s)

Description of key information

Key information for Acetophenone:
Information on aerobic and anaerobic degradation of acetophenone are available. In the study conducted according to OECD Guideline 301C, acetophenone proved to be readily biodegradable and fulfilling the 14 d window criterion (64.7% biodegradation after 14 d). A number of supportive studies confirm this result obtained at the well-known stringent conditions of the MITI Test (very high ratio substance/inoculum). 
Under anaerobic conditions, acetophenone was biodegraded neither in the standard test nor in the low concentration test in appreciable amounts (general: 30% biodegradation after 28 d; in the low concentration test: 15% degradation after 28 d, value taken from a figure). Benzoic acid (reference substance) was biodegraded by more than 78% after 14 d.
Key information regarding the Reaction mass of acetophenone and hydratropaldehyde and (E)-1,4-diphenyl-2-butene-1,4-dione:
Based on the available data for a high percentage of the constituents, the multi constituent substance is regarded as at least inherently biodegradable. No further testing regarding the Ready biodegradability (9.2.1.1 of Annex VII, REACH) is considered appropriate. This procedure is in compliance with the general rules contained in Annex XI, REACH (see detailed discussion below).

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

Discussion regarding Acetophenone:

The aerobic biodegradation was investigated in a study conducted according to OECD Guideline 301C ' Ready biodegradability: Modified MITI Test (I)' and judged as valid with restrictions due to some missing information. The study on the anaerobic biodegradation of acetophenone was judged as reliable with restrictions as the study is documented in sufficient detail and the methods applied meet generally accepted scientific principles.

Discussion regarding the Reaction mass of acetophenone and hydratropaldehyde and (E)-1,4-diphenyl-2-butene-1,4-dione

No tests regarding biodegradability are available with the registered substance. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labelling on the available data and classification of the known main and relevant constituents was used.

 

Table Main constituents of the registered substance and other relevant substances that were analytically determined and respective data on biodegradability

Substance (other names), main constituents marked in bold letters

CAS

LL (%)

UL (%)

typical concentration (%)

biodegradability data

(E)-1,4-diphenyl-2-butene-1,4-dione (trans-1,2-Dibenzoylethylene)

959-28-4

3

10

5.5

no data

1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene (dim. A-MS)

6362-80-7

1

2.2

1.9

not readily biodegradable; inherently biodegradable (OECD 302 C: mean of 64% degradation, after 28 days) (ECHA-Information on registered substance)

2-phenylpropan-2-ol (DMPC)

617-94-7

0.5

5

1.6

no data

acetophenone (Acvph)

98-86-2

40

80

69

64,7%/14d (OECD 301 C). --> readily biodegradable

cresol

1319-77-3

2

4

0.71

p-cresol: 80 to 95% were degraded within 40 days, OECD 301 C, activated sludge (Desai et al., 1990)

o-cresol: 80 to 95 % were degraded within 40 days, OECD 301 C, activated sludge (Desai et al., 1990)

m-cresol: 90 % after 28 d, OECD 302 D, closed bottle test, sewage (study report, 2002) (based onECHA-Information on registered substance)

hydratropaldehyde (Phenylpropionaldehyd-2)

93-53-8

5

20

8.5

no data

phenol

108-95-2

0.1

0,5

0.11

activated sludge 62 %/100 h, readily biodegradable (OECD 301C);

activated sludge (anaerob): 80,1 %/50 d, readily biodegradable under anaerob conditions(ECETOC-Method).

Water: 86–96 %/20 d, readily biodegradable (BOD-Test APHA)

β,β-dimethylstyrene

768-49-0

0.2

5

1.2

no data

unknown constituents

 

1

15

11.5

no data

 

Data on Biodegradability is available for the main constituent Acetophenon (with up to 80% concentration) and the impurities1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene and Phenol. For the impurity isomeric mixture cresol (CAS1319-77-3) results for the isomerso-, m-, p-cresol were extrapolated to cresol by the REACH registrants (based on available disseminated information by ECHA).

Based on the available data for a high percentage of the constituents, the multi constituent substance is regarded as at least inherently biodegradable. No further testing regarding the Ready biodegradability (9.2.1.1 of Annex VII, REACH) is considered appropriate. This procedure is in compliance with the general rules contained in Annex XI, REACH.

However it needs to be pointed out that there is no data available with regard to biodegradability for a minor part of the substance composition.

 

References

Desai S, Govind R, Tabak H, ACS Symp. Ser. 422: 142-156, 1990

ECHA: http://echa.europa.eu/information-on-chemicals