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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

No tests are available for the substance under registration. However, the main constituent Acetophenone is regarded as most relevant for the evaluation of the multi consituent substance. Therefore, the results of the test with Acetophenone were presented. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labelling on the available data and classification of the known main and relevant constituents was used. Based on this evaluation no further testing is indicated to be neccessary. 
'With regard to the main constituent Acetophenon:
The toxicity of acetophenone to Raphidocelis subcapitata was investigated in a study conducted according to OECD guideline 201. The study was conducted under static conditions in stoppered BOD bottles. The acetophenone concentration was monitored analytically. The NOEC, 72 h ECb50, and 72 h-ECr50 were determined to be 24.8 mg/L, 40 mg/L (95% C.I.: 22.9-57.1 mg/L), and 86.4 mg/L (95% C.I.: 74.6-96.2 mg/L; effective), respectively.

Key value for chemical safety assessment

Additional information

No tests are available with the registered substance. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labelling on the available data and classification of the known main and relevant constituents was used.

 

Table Main constituents of the registered substance and other relevant substances that were analytically determined and respective data on Growth inhibition study on aquatic plants (pref. Algae) and classification with regard to hazards to the aquatic environment according to CLP regulation (1272/2008/EG)

Substance (other names), main constituents marked in bold letters

CAS

LL (%)

UL (%)

typical concentration (%)

toxicity testing onalgae

Classification with regard to environmental hazards to the aquatic environment

(E)-1,4-diphenyl-2-butene-1,4-dione (trans-1,2-Dibenzoylethylene)

959-28-4

3

10

5.5

no data

not classified

1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene (dim. A-MS)

6362-80-7

1

2.2

1.9

72 h ErC50 (P. subcapitata) >0.059 mg/L (maximum attainable concentration from the maximum water soluble fraction using solvent N,N-dimethylformamide) (based onECHA-Information on registered substance)

acute aquatic tox cat 1 H400

2-phenylpropan-2-ol (DMPC)

617-94-7

0.5

5

1.6

no data

not classified

acetophenone(Acvph)

98-86-2

40

80

69

EC50/NOEC (P. subcapitata), 72 h = 86.4/ 24.8 mg/L

not classified

cresol

1319-77-3

0.2

4

0.71

p-cresol: EC50 (48 h): 21 mg/L (growth rate)Desmodesmus subspicatus(Kuehn et al. 1990, based onECHA-Information on registered substance)

not classified

hydratropaldehyde (Phenylpropionaldehyd-2)

93-53-8

5

20

8.5

no data

not classified

phenol

108-95-2

0.1

0.5

0.11

EC50 (P. subcapitata, 96 h) = 61.1 mg/L (SDS, Domo)

not classified

β,β-dimethylstyrene

768-49-0

0.2

5

1.2

no data

not classified

unknown constituents

 

1

15

11.5

no data

not classified

 

Algae data is available for the main constituent Acetophenon (with up to 80% concentration) and the impurities 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene, cresol and Phenol. For the impurity isomeric mixture cresol (CAS 1319-77-3) data is available for the isomer p-cresol only which is considered suitable to assess the isomeric mixture cresol (based on available disseminated information by ECHA). No data on growth inhibition study with Algae is available for (E)-1,4-diphenyl-2-butene-1,4-dione and hydratropaldehyde and the impurities 2-phenylpropan-2-ol2-phenylpropan-2-ol and β,β-dimethylstyrene β,β-dimethylstyrene.

The environmental hazards (Hazardous to the aquatic environment) assessment is based on available information on the hazards for each of the containing substances. The procedure laid down in section 4.1.3. (Classification criteria for mixtures) of annex I of the CLP-Regulation (1272/2008 (EC)) was used. Data are available for most of the relevant constituents and impurities, however for a minor but however relevant amount (concentration) of constituents data are missing. Data is available for one constituent that is classified as Acute 1 and others that are not classified. For this part of the mixture (multi constituent substance) the combined toxicity towards algae is calculated using the additivity formula using algae data only. For final classification according to CLP regulation the summation method (4.1.3.5) was applied.

The additivity formula for acute aquatic toxicity under section 4.1.3.5.2 of annex I, CLP regulation was applied to calculate the EC50mix for 71.7% of the multi constituent substance under registration:

 

The total concentration of the constituents and impurities with unknown toxicity towards algae is 28.3 % (based on typical concentrations).

The calculated short term EC50mix (for algae) of 36.1 mg//L accounts for the constituents and impurities with known toxicity (71.7 %, for the typical concentrations).

Based on the procedure laid out above the toxicity towards algae was evaluated and a classification for the (multi constituent) substance was concluded. Thus, no further testing regarding the Growth inhibition study on aquatic plants (9.1.2 Annex VII, REACH) is considered appropriate. By using this above procedure this adaption to the short term toxicity testing on aquatic invertebrates is in compliance with the general rules contained in Annex XI, REACH.

References

Kuehn R, Pattard M, Water Res. 24(1), 31-38, 1990. (cited in ECHA)

ECHA: http://echa.europa.eu/information