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EC number: 941-360-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No tests are available for the substance under registration. However, the main constituent Acetophenone is regarded as most relevant for the evaluation of the multi consituent substance. Therefore, the results of the test with Acetophenone were presented. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labelling on the available data and classification of the known main and relevant constituents was used. Based on this evaluation no further testing is indicated to be neccessary.
'With regard to the main constituent Acetophenon:
The toxicity of acetophenone to Raphidocelis subcapitata was investigated in a study conducted according to OECD guideline 201. The study was conducted under static conditions in stoppered BOD bottles. The acetophenone concentration was monitored analytically. The NOEC, 72 h ECb50, and 72 h-ECr50 were determined to be 24.8 mg/L, 40 mg/L (95% C.I.: 22.9-57.1 mg/L), and 86.4 mg/L (95% C.I.: 74.6-96.2 mg/L; effective), respectively.
Key value for chemical safety assessment
Additional information
No tests are available with the registered substance. The procedure laid down in the CLP regulation (1272/2008/EG) to base the classification and labelling on the available data and classification of the known main and relevant constituents was used.
Table Main constituents of the registered substance and other relevant substances that were analytically determined and respective data on Growth inhibition study on aquatic plants (pref. Algae) and classification with regard to hazards to the aquatic environment according to CLP regulation (1272/2008/EG)
Substance (other names), main constituents marked in bold letters |
CAS |
LL (%) |
UL (%) |
typical concentration (%) |
toxicity testing onalgae |
Classification with regard to environmental hazards to the aquatic environment |
(E)-1,4-diphenyl-2-butene-1,4-dione (trans-1,2-Dibenzoylethylene) |
959-28-4 |
3 |
10 |
5.5 |
no data |
not classified |
1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene (dim. A-MS) |
6362-80-7 |
1 |
2.2 |
1.9 |
72 h ErC50 (P. subcapitata) >0.059 mg/L (maximum attainable concentration from the maximum water soluble fraction using solvent N,N-dimethylformamide) (based onECHA-Information on registered substance) |
acute aquatic tox cat 1 H400 |
2-phenylpropan-2-ol (DMPC) |
617-94-7 |
0.5 |
5 |
1.6 |
no data |
not classified |
acetophenone(Acvph) |
98-86-2 |
40 |
80 |
69 |
EC50/NOEC (P. subcapitata), 72 h = 86.4/ 24.8 mg/L |
not classified |
cresol |
1319-77-3 |
0.2 |
4 |
0.71 |
p-cresol: EC50 (48 h): 21 mg/L (growth rate)Desmodesmus subspicatus(Kuehn et al. 1990, based onECHA-Information on registered substance) |
not classified |
hydratropaldehyde (Phenylpropionaldehyd-2) |
93-53-8 |
5 |
20 |
8.5 |
no data |
not classified |
phenol |
108-95-2 |
0.1 |
0.5 |
0.11 |
EC50 (P. subcapitata, 96 h) = 61.1 mg/L (SDS, Domo) |
not classified |
β,β-dimethylstyrene |
768-49-0 |
0.2 |
5 |
1.2 |
no data |
not classified |
unknown constituents |
|
1 |
15 |
11.5 |
no data |
not classified |
Algae data is available for the main constituent Acetophenon (with up to 80% concentration) and the impurities 1,1'-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene, cresol and Phenol. For the impurity isomeric mixture cresol (CAS 1319-77-3) data is available for the isomer p-cresol only which is considered suitable to assess the isomeric mixture cresol (based on available disseminated information by ECHA). No data on growth inhibition study with Algae is available for (E)-1,4-diphenyl-2-butene-1,4-dione and hydratropaldehyde and the impurities 2-phenylpropan-2-ol2-phenylpropan-2-ol and β,β-dimethylstyrene β,β-dimethylstyrene.
The environmental hazards (Hazardous to the aquatic environment) assessment is based on available information on the hazards for each of the containing substances. The procedure laid down in section 4.1.3. (Classification criteria for mixtures) of annex I of the CLP-Regulation (1272/2008 (EC)) was used. Data are available for most of the relevant constituents and impurities, however for a minor but however relevant amount (concentration) of constituents data are missing. Data is available for one constituent that is classified as Acute 1 and others that are not classified. For this part of the mixture (multi constituent substance) the combined toxicity towards algae is calculated using the additivity formula using algae data only. For final classification according to CLP regulation the summation method (4.1.3.5) was applied.
The additivity formula for acute aquatic toxicity under section 4.1.3.5.2 of annex I, CLP regulation was applied to calculate the EC50mix for 71.7% of the multi constituent substance under registration:
The total concentration of the constituents and impurities with unknown toxicity towards algae is 28.3 % (based on typical concentrations).
The calculated short term EC50mix (for algae) of 36.1 mg//L accounts for the constituents and impurities with known toxicity (71.7 %, for the typical concentrations).
Based on the procedure laid out above the toxicity towards algae was evaluated and a classification for the (multi constituent) substance was concluded. Thus, no further testing regarding the Growth inhibition study on aquatic plants (9.1.2 Annex VII, REACH) is considered appropriate. By using this above procedure this adaption to the short term toxicity testing on aquatic invertebrates is in compliance with the general rules contained in Annex XI, REACH.
References
Kuehn R, Pattard M, Water Res. 24(1), 31-38, 1990. (cited in ECHA)
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