Butyl(ethyl)amine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979-05-01

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted standards with acceptable restrictions (limited documentation; raw data generally available on request)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Principles of method if other than guideline:

Method: other: no data

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Butyl(ethyl)amine

EC Number:

236-415-0

EC Name:

Butyl(ethyl)amine

Cas Number:

13360-63-9

Molecular formula:

C6H15N

IUPAC Name:

butyl(ethyl)amine

Details on test material:

- Name of test material (as cited in study report): N-Ethyl-N-n-butylamin; no further details

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

nose/head only

Vehicle:

air

Details on inhalation exposure:

no data

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

1 h

Concentrations:

2.45, 9.66, 10.18, and 11.87 mg/m3 (analytical)

No. of animals per sex per dose:

10

Control animals:

other: not required

Details on study design:

- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LC50

Effect level:

10.6 mg/L air (analytical)

Exp. duration:

1 h

Effect levels 2

Sex:

female

Dose descriptor:

LC50

Effect level:

> 11.9 mg/L air (analytical)

Exp. duration:

1 h

Any other information on results incl. tables

 

Concentration (mg/L; analytical	Mortality No. dead /No. exposed
	Male	female
2.45	0/10	0/10
9.66	2/10	0/10
10.18	5/10	0/10
11.87	8/10	0/10

 

Applicant's summary and conclusion

Executive summary:

10 male and female Wistar rats were exposed (head-nose only) to Butylethylamine for 1 hour at analytical concentrations of 2.45 to 11.87 mg/L. All females survived whereas male mortality increased with dose up to 80% at the top dose. The LC_50(1hr)was 10.6 mg/L for the male rat (BASF, 1979).

The study may be used for assessment using the LC_{50, 1 -hr} -value for male rats. There is no explanation why no deaths occurred in females.