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EC number: 435-740-7 | CAS number: 94317-64-3
The study was performed to assess the acute oral toxicity of the test material in the young adult albino rats of the Crl:CD®(SD)BR strain procured from Charles River Laboratories, Inc., Portage, Michigan. The method was designed to meet the EPA Guidelines: EPA OTS 798.1175 (Acute Oral Toxicity).
The objective of this study was to assess the acute oral toxicity produced when the test material is administered by the oral route (gavage) to rats.
The test material, N-(n-butyl) thiophosphoric triamide (NBPT), was evaluated for its acute oral toxicity potential in male and female rats when administered as a single gavage dose at levels of 1000, 2500, and 5000 mg/kg of body weight in males and at 1000, 2500, and 3000 mg/kg in females. The estimated oral LD50 in rats was determined to be 3536, 2603, and 2823 mg/kg for males, females, and the sexes combined, respectiv
All mortality occurred within 2 days of test material administration.
Clinical signs of toxicity included thin appearance, hunched posture, staggered gait, hypoactivity, absence of pain and/or righting reflex, hypothermic to touch, prostration, red or yellow-stained face, lacrimation, miosis, excessive salivation, dyspnoea, bradypnoea, soft stool, wet urogenital area, and dark- or yellow-stained urogenital area. All surviving animals returned to a normal appearance by Day 5 after treatmen
There was no meaningful effect on body weight gain in surviving animal.
Test material-related findings observed at necropsy were limited to those animals dying during the study and pertained to coloration changes and the contents of the gastrointestinal tract.
The acute oral median lethal dose (LD50) of the test material in the female Wistar strain rat was estimated to be greater than 2000 mg/kg bodyweight.
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