[No public or meaningful name is available]

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Additional information

Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene is a multiconstituent substance containing

(611 -06 -3) 2,4 -Dichloronitrobenzene : 50 -80 %

(601 -88 -7) 2,6.-Dichloronitrobenzene: 10 -50 %

(89 -61 -2) 2,5 -Dichloronitrobenzene 0 -5 %

(541 -73 -1) 1,3 Dichlorobenzene 0 -<1 %

mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene 0 -10 %

There is no study availabe to evaluate the effects on fertility with reaction mass of 2,4 -DCNB and 2,6DCNB and there are no studies available with 601- 88 -7; 541 -73 -1 and the mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene

611 -06 -3

2,4 -DCNB was studied for oral toxicity in rats according to the OECD combined repeat dose and reproductve/developmental toxicity test (OECD TG 422) at doses of 0. 8, 40, and 200 mg/kg bw/day. The substance showed no effects on mating, ferility or estrus cycle.

One female given 200 mg/kg bw/day died during delivery. All pups were stillborn with two females and pups died during lactation period with three females given 200 mg/kg bw/day. In addition, the number of live pups born decreased and number of stillborn pups tended to increase. The live birth index viability index of pups at day 4 after birth and delivery index were decreased or showed a tendency for decrease in the same group suggesting functional disturbances in delivery or lactation caused by the test substance. The NOEL for Reproductive toxicity was considered to be 40 mg/kg bw/day for parental animals and offspring. With regard to repeat dose toxicity, a NOAEL of 8 mg/kg bw/day was established based on effects on liver, kidneys and blood (Kawamura 1996).

89 -61 -2

2,5 - DCNB was studied for its oral toxicity in rats in an OECD preliminary reproduction toxicity screening test at doses of 0, 6, 20, 60. and 200 mg/kg bw/day. Based on general toxic effects the NOAEL was 60 mg/kg bw/day. Male reproductive performance was not affected by treatment (NOAEL 200 mg/kg bw/day); The NOAEL for female reproductive performance was considered to be 20 mg/kg bw/day based on mortality and perinatal impairment at 60 mg/kg bw/day and more. For pups there are indications that growth was affected by treatment at the highest test dose resulting in a NOAEL of 60 mg/kg bw/day in terms of reproductive developmental toxicological effects.

Short description of key information:
There is no reproductive toxicity study available using the reaction mass of 2,4-DCNB and 2,6-DCNB.

Effects on developmental toxicity

Additional information

Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene is a multiconstituent substance containing

(611 -06 -3) 2,4 -Dichloronitrobenzene : 50 -80 %

(601 -88 -7) 2,6.-Dichloronitrobenzene: 10 -50 %

(89 -61 -2) 2,5 -Dichloronitrobenzene 0 -5 %

(541 -73 -1) 1,3 Dichlorobenzene 0 -<1%

mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene 0 -10 %

There is no developmental toxicity study available with the reaction mass of 2,4 -Dichloronitrobenze and 2,6 -Dichloronitrobenzene.

Justification for classification or non-classification

No reliable data are available. The limited data on some compounent do not indicate developmental toxicity.