Registration Dossier
Registration Dossier
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EC number: 939-509-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Based on the available acute toxicity data of the constituents of Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene taking into account the main constituent, it can be assumed that the overall LD50(oral) is about 376 mg/kg bw and the overall LD50 (dermal) is about 921 mg/kg bw. With respect to acute inhalation toxicity no reliable conclusion can be drawn.
Key value for chemical safety assessment
Additional information
Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene is a multiconstituent substance containing
(611 -06 -3) 2,4 -Dichloronitrobenzene : 50 -80 %
(601 -88 -7) 2,6.-Dichloronitrobenzene: 10 -50 %
(89 -61 -2) 2,5 -Dichloronitrobenzene 0 -5 %
(541 -73 -1) 1,3 Dichlorobenzene 0 -< 1 %
(99 -54 -7) 3,4 -Dichloronitrobenzene : 0 -<1 %
mixture of 4,6 -dichloro-1,3 -dinitrobenzene and 2,4 -dichloro-1,3 -dinitrobenzene 0 -10 %
ACUTE ORAL TOXICITY
LD50 (oral rat)
376 mg/kg bw (611 -06 -3);
2503 mg/kg bw (89 -61-2)
580 mg/kg bw (541 -73 -1)
625 mg/kg bw (99 -54 -7)
no data available for 601 -88 -7; and for the above cited mixture
ACUTE INHALATION TOXICITY
89 -61 -2: no rat died during 7 hour exposure against 47.6 mg/m³/h
no data available from the other costituents
ACUTE DERMAL TOXICITY
LD50(dermal, rat)
921 mg/kg bw (611 -06 -2)
> 2000 mg/kg bw (89 -61 -2)
> 2000 mg/kg bw (99 -54 -7)
no data available from the other constituents
OVERALL CONCLUSION
Based on the available acute toxicity data of the constituents of Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitr obenzene taking into account the main constituent, it can be assumed that the overall LD50(oral) is about 376 mg/kg bw and the overall LD50 (dermal) is about 921 mg/kg bw. With respect to acute inhalation toxicity no reliable conclusion can be drawn.
Justification for classification or non-classification
Based on the available acute toxicity data of the constituents of Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -Dichloronitrobenzene, this reaction mass has to be allocated to category 4 (H302) of the acute oral toxic substances and category 3 (H311) of acute dermal toxic substances according to Regulation (EC) 1272, 2008 (GHS). According to Regulation 67/548/EWG Reaction mass of 2,4 -Dichloronitrobenzene and 2,6 -dichloronitrobenzene is evaluated as harmfull if swallowed and if contact with skin occurs (R22/21)
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