Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Irritation was evaluated as part of phototoxicity study, in which 15 non-haired mice (hairless:hrhr) were given a single dermal application of the undiluted test material (20 ul) on an area of skin measuring approximately 5-cm2. Treated skin that was not exposed to the light was evaluated for irritation. The positive control was a 0.01% solution of 8-methoxypsoralen (8-MOP) in methanol, and the negative control was the vehicle (methanol) alone. If dilutions were necessary, the test material was diluted in methanol.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Cornmint oil
IUPAC Name:
Cornmint oil

Test animals

Species:
mouse
Strain:
other: Hairless hrhr

Test system

Type of coverage:
not specified
Preparation of test site:
other: Hairless mice
Vehicle:
other: Methanol
Number of animals:
15 mice

Results and discussion

In vivo

Irritant / corrosive response data:
No irritant effect observed.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
Cornmint oil did not shown any irritant effect. Thus, it is not considered as an irritating substance for skin.