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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A dermal DL50 was conducted in which 10 rabbits received a dermal application of 5g/lg of the test material. The animals were observed for mortality and/or systemic effects for 14 days.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Cornmint oil
IUPAC Name:
Cornmint oil

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
14 days
Doses:
0.5 g/kg to 5 g/kg
No. of animals per sex per dose:
10 rabbits per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Distribution of mortality: no death within 14 days
Clinical signs:
Symptomatology: sloughing of skin 12 days post-dosage

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal DL50 in rabbits is higher than 5 g/kg or 5000 mg/kg.bw.
According to the CLP Regulation, this DL50 does not trigger any classification as acutely toxic, dermal.