Registration Dossier
Registration Dossier
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EC number: 608-209-4 | CAS number: 284461-73-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 0.012 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
The test item is highly unsoluble in water. The determined water solubiliity was close to the detection limit and decreased over the test period to below the detection limit.
- Validity criteria fulfilled:
- yes
- Conclusions:
- BAY 43-9006 is not toxic to fish up to the solubility limit.
- Executive summary:
A study was performed to assess the acute toxicity of BAY 43-9006 to fish Danio rerio. A group of 10 fish were exposed to the test compound or a control in a limit test.The test concentration was 0.5 mg/L (nominal). The test material was ultrasonified and filtered.
The chemical analysis showed a recovery of <5%, partly below the detection limit. Observations on letality and behaviour of fish were made 2, 24, 48, 72, and 96 hours after start of exposure.
No effects on mortality of abnomal behaviour was observed. Thus, the LC0 was equal or higher than the maximum solubility under the conditions of the test (<0.012 mg/L). Hence, the compound is not toxic to fish.
Reference
Description of key information
A guideline study according to EU Method C.1 (Acute Toxicity for Fish) was performed under GLP to assess the acute toxicity of BAY 43-9006 to fish Danio rerio. A group of 10 fish were exposed to the test substance or a control in a limit test. The test concentration was 0.5 mg/L (nominal). The test substance was ultrasonified and filtered. The test substance is highly unsoluble in water. The determined water solubiliity was close to the detection limit and decreased over the test period to below the detection limit (chemical analysis showed a recovery of <5%). Observations on letality and behaviour of fish were made 2, 24, 48, 72, and 96 hours after start of exposure. No effects on mortality of abnomal behaviour was observed. Thus, the LC0 was equal or higher than the maximum solubility under the conditions of the test (<0.012 mg/L). Hence, the test substance is not toxic to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- >= 0.012 mg/L
Additional information
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