Registration Dossier
Registration Dossier
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EC number: 608-209-4 | CAS number: 284461-73-0
Endpoint summary
Administrative data
Description of key information
The test substance BAY 43-9006 is highly insoluble in water (< 0.1 mg/L), has a moderate to high adsorption potential (logKoc =3.6) and a low vapour pressure (4.1E-11Pa at 25°C). Its main environmental target compartment is therefore expected to be soil and sediment. Due to the low water solubility, the substance is expected to be removed in a primary settling tank of sewage treatment plants. Significant release into surface waters is therefore unlikely. The substance is expected to be hydrolytically stable under environmental conditions, and significant biodegradation is not expected according to OECD 301 screening test in water, OECD 308 simulation test in sediment and OECD 307 aerobic transformation test in soil. A bioaccumulation factor of 7300 has been established for the test substance, furthermore due to its logKow = 3.3 a high potential for bioaccumulation can be concluded. Exposure to aquatic organisms will be extremely low due to the low water solubility of the substance.
Additional information
Hydrolysis: In accordance with REACH Annex VIII column 2, the study does not need to be conducted as the substance is highly insoluble in water.
Biodegradation in water: In the study on ready biodegradability a degradation rate of 2 % was determined within 28 days for the test substance. The substance is considered to be "Not Readily Biodegradable".
Biodegradation in sediment: In a sediment simulatioon test, the test substance was removed rapidly from the water fraction and bound to the sediment in both sediment (DT50 for water was < 1 day). Ultimate biodegradation in sediment was low and accounted for <1.1%. Because of the lack of relevant biodegradation, the test item is assumed to accumulate in the sediment.
Biodegradation in soil: Within an aerobic transformation study in soil the DT50 of the test substance in arobic sandy loam soil Sevelen were calculated to be 187 days. No major metabolites were detected and only minor mineralization to CO2 was observed throughout the study. The degradation of the test substance is accompanied by increasing levels of non-extractable residues in soil. Overall, the test substance is only slowly degraded in soil under aerobic conditions.
Bioaccumulation: The bioaccumulation factor of the test substance derived by the QSAR determination was 69.9 L/kg (ww) and showed that the test substance has a low potential to bioaccumulate in biota. An experimental fish study showed a bioaccumulation factor of 7300, demonstrating that the compound has a high potential for bioaccumulation.
Adsorption/desorption: The QSAR determination of the carbon partition coefficient revealed values of 476.7 L/kg (logKow method) and 4414 L/kg (MCI method). This corresponds to a logKoc between 2.68 - 3.64, thus the substance can be regarded as moderately adsorptiv (log Koc > 3).
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