2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Aug 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

>= 0.031 mg/L

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

dissolved

Basis for effect:

mortality

Validity criteria fulfilled:

yes

Conclusions:

The test susbtance is not toxic to Daphnia magna up to the solubility level.

Executive summary:

20 Daphnia were exposed to BAY 43 -9006 in a saturated solution (nominal concentration: 0.5 mg/L) and a control in a limit test over a period of 48h. Immobilization was recorded at 24 and 48 h. No immobilized Daphnia were observed during the test. Thus the EC0 was higher than a saturated solution, measured with </= 0.031 mg/L.

Description of key information

A guideline study according to OECD Guideline 202 (Daphnia sp. Acute Immobilization Test) was performed under GLP to assess the acute toxicity of BAY 43-9006 to Daphnia magna. A group of 20 Daphnia were exposed to BAY 43 -9006 in a saturated solution (nominal concentration: 0.5 mg/L) and a control in a limit test over a period of 48h. Test concentrations were analysed by HPLC/UV. Due to the low solubility of the test substance, the test concentration of the saturated solution was determined to be approximately between 0.031 and 0.047 mg/L. Observations on immobilization of Daphnia were recorded at 24 and 48 h after start of exposure. No immobilized Daphnia were observed during the test. Thus the EC0 was higher than the maximum solubitlity under the test conditions (measured concentration >/= 0.031 mg/L). Hence, the test susbtance is not toxic to Daphnia magna up to the solubility level.

 

 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Dose descriptor:

EC50

Effect concentration:

>= 0.031 mg/L