Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

column elution method

Water solubility:

7 mg/L

Temp.:

20 °C

pH:

>= 7.2 - <= 7.7

column 1 (12 mL/h)			column 2 (24 mL/h)
fraction no.	pH value	concentration [mg/L]	fraction no.	pH value	concentration [mg/L]
8	7.8	7.0	1	7.5	8.3
9	7.7	7.2	2	7.5	8.1
10	7.6	7.1*	3	7.7	7.9
11	7.5	7.1*	4	7.5	8.4
12	7.5	7.1*	5	7.6	7.3
13	7.5	7.1*	6	7.4	7.3*
14	7.7	7.1*	7	7.4	7.1*
15	7.7	7.2	8	7.6	6.7*
16	7.8	7.2	9	7.2	6.9*
17	7.4	7.2	10	7.5	6.8*

* fractions used for determination

mean value of both columns: 7.0 mg/L

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the substance is 7.0 mg/L at 20°C.

Executive summary:

Determined according to the guideline EU Method A.6, using the column elution procedure, the water solubility of the substance was 7.0 mg/L at 20°C.

Description of key information

The water solubility of the substance is 7.0 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:

7 mg/L

at the temperature of:

20 °C

Additional information

Determined according to the guideline EU Method A.6, using the column elution procedure, the water solubility of the substance was 7.0 mg/L at 20°C.