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Physical & Chemical properties

Particle size distribution (Granulometry)

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particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
according to guideline
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
Version / remarks:
(method B)
GLP compliance:
Type of method:
other: Sieving followed by electron microscopy.
Type of distribution:
counted distribution
Mass median aerodynamic diameter:
66.5 µm
Remarks on result:
other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

The sample was first sieved by a 100 µm sieve.

weighted sample: 1.3414 g

weight fraction < 100 µm: 0.2856 g

mass fraction < 100 µm: 21.29 %

Result: Particle Size Distribution of the sieve fraction nominal < 100 µm

10.16 %: 2 - 3 µm

29.30 %: 3 - 5 µm

60.54 %: 5 - 100 µm

statistical data:

 Counts  1191  
   Mean diameter [¿m]  Aspect Ratio
 Minimum  2.36 1.00
 Maximum  99.92 11.67
 Arithmetic mean  13.42 1.79
 Median  6.19 1.67
 Standard deviation  16.71 0.63

Result: Mass Fraction (calculated) of the sieve fraction nominal < 100 µm:

Particle size   spherical volume [%]  cubical volume [%]
 < 4 µm (respirable)  0.04  0.07
 4 - 10 µm (thoracic)  0.44  0.65
 10 - 100 µm (inhalable)  99.52 99.28
 > 100 µm  0.00  0.00
 Median (diameter µm)  66.50 62.32

Median diameter corresponds to MMAD (Mass Median Aerodynamic Diameter).


 Accounting based on the total sample weight    
   Particle Size [¿m]  Spherical Volume [%]
 Mass Fraction  >100  78.71
 Sieve Fraction  >100  0.00
 Total (>100¿m)    78.71
 Sieve Fraction  10-100 (inhalable)  21.19
 Sieve Fraction  4-10 (thoracic)  0.09
 Sieve Fraction  <4 (respirable)  0.01
The MMAD (Mass Median Aerodynamic Diameter < 100 µm) has a value of 66.5 µm as spherical particles.
Executive summary:

According to OECD guideline 110, the particle size distribution of the substance was determined by scanning electron microscopy method for the sieved fraction (< 100 µm, 21.29 % of total sample) and presented on the basis of calculated mass fractions. The median diameter was 66.5 µm with the main fraction of 99.52 % distribution in the rang of 10 - 100 µm; and hence the tested substance particles with sieved size smaller than 100 µm are mainly dominated by inhalable fraction as defined in EN 481.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100¿m) has a value of 66.5 ¿m as spherical particles.

Additional information