Registration Dossier

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to OECD guideline, no indication if GLP, not all of the required measures are distributed

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report Date:
1993

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
not specified
Principles of method if other than guideline:
-
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
activated sludge of a predominantly domestic sewage

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
3 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
430 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
EC0
Effect conc.:
22.8 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Any other information on results incl. tables

see attachement

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The 30 minute and 3 hour EC50 for inhibition of the respiration rate of aerobic waste water bacteria for C3-Phosphoniumbromid is
> 100 mg/l (nominal concentration).
Executive summary:

A test was conducted to determine the inhibitory concentration of C3 -Phosphoniumbromide on the respiration of aerobic waste water bacteria according to OECD guideline for testing of chemicals 209. The durations of exposure tested were 30 minutes and 3 hours. The EC50 (30 min) and the EC50 (3 hr) were found to be >100 mg/l based on the nominal concentrations.