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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 16th 2011 to june 3rd 2011
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Deviations:
no
Principles of method if other than guideline:
The principle of this evaluation is based on the measurement of two factors: the opacity and the permeability of the treated corneas. The changes in these parameterrs correspond to the damages induced to the tissues.
The method used is adapted from that described by Gautheron P. & al. (1992) Fundam. Appl. Toxicol. 18 442-449.
GLP compliance:
yes (incl. certificate)
Remarks:
Certificate on April 7th 2010

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 30 MINUTES
Score:
1.5
Max. score:
3.8
Reversibility:
not specified
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 4 hours
Score:
6.5
Max. score:
13.7
Reversibility:
not specified

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the experimental conditions of the study, according to the mean in vitro scores of 30-minutes and 4-hour treatments, the test item, EPOXY RESIN T1600, tested in its original form, is classified as Class 1, slightly irritant for the isolated calf cornea.