Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 24th 2011 to June 20th 2011
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Certificate n°: GIPC 2011/13 March 7th 2011

Test material

Reference
Name:
Unnamed
Type:
Constituent
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Duration of testopen allclose all
Duration:
5 d
pH:
1.2
Temp.:
50 °C
Initial conc. measured:
8.3 mg/L
Duration:
5 d
pH:
4.5
Temp.:
50 °C
Initial conc. measured:
10.8 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
8.5 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
12.8 mg/L

Results and discussion

Transformation products:
yes
Identity of transformation products
No.:
#1
Reference
Reference substance name:
Unnamed
IUPAC name:
Dissolved organic carbon
Identifier:
common name
Identity:
Dissolved organic carbon
Total recovery of test substance (in %)open allclose all
% Recovery:
4.92
St. dev.:
19.2
pH:
1.2
Temp.:
50 °C
Duration:
5 d
% Recovery:
8.14
St. dev.:
31.8
pH:
4.5
Temp.:
50 °C
Duration:
5 d
% Recovery:
9.04
St. dev.:
35.3
pH:
7
Temp.:
50 °C
Duration:
5 d
% Recovery:
3.23
St. dev.:
12.6
pH:
9
Temp.:
50 °C
Duration:
5 d

Any other information on results incl. tables

The hydrolysis as a function of pH of the test item Epoxy Resin T1600 was assessed according to the OECD guideline 111.

The objective of the study was to determine the rate of hydrolysis of the test item in different buffers and at different temperatures.

The preliminary test showed that the item was stable at pH 1.2,4.5, 7 and 9 at 50°C. After 5 days, less than 10% of hydrolisis were observed through analysis of dissolved organic carbon.

As specified in the OECD guideline 111, EPOXY RESIN T1600 is considered as hydrolytically stable and no additionnal testing is required.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
As specified in the OECD guideline 111, EPOXY RESIN T1600 is considered as hydrolytically stable and no additionnal testing is required.