Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-429-2
CAS number: 816-19-3
The study was performed to US EPA OPPTS 870.2500 and OECD
405 to assess the primary skin irritancy potential of the test substance
in accordance with GLP. Five-tenths of a milliliter of the test
substance was applied to one 6 cm2 intact dose site on each animal and
covered with a 1 inch x 1 inch, 4-ply gauze pad. The pad and entire
trunk of each animal were then wrapped with semi-occlusive 3 inch
Micropore tape to avoid dislocation of the pad. After 4 hours of
exposure to the test substance, the pads and collars were removed and
the test sites were gently cleaned of any residual test substance.
Individual dose sites were scored according to the Draize scoring system
at approximately 1, 24, 48, and 72 hours and at 7, 10, and 14 days after
patch removal. The classification of irritancy was obtained by adding
the average erythema and edema scores for the 1, 24, 48, and 72-hour
scoring intervals and dividing by the number of evaluation intervals.
Within 24 hours of patch removal, all three treated sites exhibited
severe erythema and very slight edema. Desquamation was noted for two
animals between Days 10 and 14. Although the overall severity of
irritation decreased gradually by the end of the study, irritation
persisted for all animals through Day 14 (study termination). The
Primary Dermal Irritation Index for the test substance is 4.5. Under the
conditions of this study the substance is classified as moderately
irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again