Registration Dossier
Registration Dossier
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EC number: 272-789-1 | CAS number: 68911-83-1
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity: oral:
Peter (2013) performed a combined repeated dose toxicity study with reproduction/developmental toxicity screening test in rats according to OECD guideline 422 (GLP). A Parental NOAEL of 100 mg/kg bw/day was derived.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available data of the OECD 422 test and the criteria of the DSD and CLP Regulation, the substance should be classified as R48/22 and STOT RE 2 H373, as significant toxic effects were observed at a concentration of 300 mg/kg bw/d (upper limit of the CLP guidance values for STOT RE category 2 - H373 classification, based on data of a 28 days repeated toxicity test via the oral route).
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