Registration Dossier
Registration Dossier
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EC number: 252-156-6 | CAS number: 34690-00-1
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Long-term testing to fish is not required at Annex VIII. In accordance with Column 2 of REACH Annex VIII, there is no need to further investigate the effects of this substance in a long-term aquatic toxicity to fish study because, in line with guidance R.7b.8.4.3 (ECHA 2017, the quantitative chemical safety assessment (conducted according to Annex I of REACH) indicates thatthe Risk Characterisation Ratio is below 1, and therefore the risk is already adequately controlled and further testing is not justifiable. Furthermore, the substance is highly water soluble and not bioaccumulative. No effects were observed in fish short-term testing below 100 mg/l, indicating low toxicity. An assessment factor of 1000 was applied to derive the freshwater PNEC using the short-term invertebrate result. The availability of the short-term result covering the most sensitive species in the aquatic tests, and the application of an appropriate assessment factor, means it is, therefore, unlikely that the aquatic PNEC would be significantly over-estimated. A PNEC has been derived for the purpose of chemical safety assessment and the risk characterisation ratios are below 1. Overall it is concluded that the risk is adequately assessed using the short-term data, and that in vivo testing on vertebrate animals is not considered necessary or justified on ethical grounds. Details on how the PNEC and the risk characterisation ratio have been derived can be found in IUCLID Section 6 Ecotoxicological information endpoint summary and Chapters 9 and 10 of the Chemical Safety Report, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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