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EC number: 252-156-6 | CAS number: 34690-00-1
No study of bioaccumulation conducted with BHMT-H is available. Given the very low estimated value of log Kow (-4), bioaccumulation is expected to be very low. A reliable study of bioaccumulation of DTPMP-xNa in carp, indicates a bioconcentration factor in the exposure phase of <10 (Concentration level 18.8mg/l) and <94 (concentration level 2.03 mg/l). No active uptake mechanisms (i.e. mediated by enzymes) can occur for phosphonates.
The registration substance is part of a category family (super-category; see CSR for more details) which consists of several phosphonates that share a common chemistry incorporating alkyl backbones with one or more tertiary amine centres and multiple methylphosphonate groups present.
BHMT acid (CAS 34690-00-1) has three amine centres (five methylphosphonate groups), connected by hexyl chains. DTPMP acid (CAS 15827-60-8) has three amine centres (five methylphosphonate groups), connected by ethyl chains.
As well as being structural analogues, both phosphonates have consistent chemical properties including high MW (685 and 573 respectively), very low log Kow(≤-3 for both substances) and are highly soluble in water. The substances generally posses similar physico-chemical properties and are not readily biodegradable.
The sodium counterion of DTPMP-xNa (22042-96-2) is not significant in respect of the properties under consideration and has been assessed in depth in the public literature.Additionally, the counterion is expected to dissociate when in contact with water, including atmospheric moisture.
Therefore, for the purpose of this assessment, read-across is considered valid. Further information on the super-category and the validity of read-across are presented in the CSR Chapter 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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