3,3'-oxybis(ethyleneoxy)bis(propylamine)

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Remarks:

test concentration unknown and co-exposure via inhalation, oral and dermal route.

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VII

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS

Year:

1969

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 30: 470-476

Materials and methods

Principles of method if other than guideline:

Groups of six male or female albino rats where wholy body exposed to a flowing stream of vapor-ladened air. The vapor-air mixture was generated by passing 2.5 litres/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approx. 50 mL of the test substance contained in a gas-washing bottle. Inhalations were continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined.

GLP compliance:

no

Test type:

other: Inhalation Hazard Test

Test material

Test material information

Constituent 1

Reference substance name:

3,3'-oxybis(ethyleneoxy)bis(propylamine)

EC Number:

224-207-2

EC Name:

3,3'-oxybis(ethyleneoxy)bis(propylamine)

Cas Number:

4246-51-9

Molecular formula:

C10H24N2O3

IUPAC Name:

3,3'-[oxybis(ethane-2,1-diyloxy)]dipropan-1-amine

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

air

Details on inhalation exposure:

Groups of six male or female albino rats where whole body exposed to a flowing stream of vapor-ladened air. The vapor-air mixture was generated by passing 2.5 litres/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approx. 50 mL of the test substance contained in a gas-washing bottle. Inhalations were continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

No vapor concentration given in the report. As the whole body was exposed oral and dermal uptake might have also occurred in addition to inhalation. Thus, no reliable vapor concntration can be derived.

No. of animals per sex per dose:

6 males or females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Dose descriptor:

LC0

Effect level:

other: unknown exposure concentration

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: No mortality. Mortality after 8-hour exposure. Co-exposure via inhalation, oral and dermal route.

Mortality:

No mortality after 4 hours exposure in an atmosphere saturated with the test substance at room temperature. Mortality after 8 hours.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

A 4 hours exposure to a flowing stream of vapor-ladened air with the test substance resulted in no mortality, whereas after 8 h exposure mortality occurred.

Executive summary:

In an acute inhalation toxicity study with whole body exposure (Smyth et al., 1969), six albino rats were exposed to a vapour atmosphere of the test substance for a series of time periods ranging from 15 minutes up to 8 hours and observed for 14 days. A 4 hours exposure to a flowing stream of vapor-ladened air with the test substance resulted in no mortality, whereas after 8 h exposure mortality occurred. This study is not valid and therefore disregarded because the vapor concentration is unknown and co-exposure via inhalation, oral and dermal route occurred.