Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 257-804-1
CAS number: 52277-71-1
Following the experimental design according to Federal Register 38, No.
187 § 1500.42, 1973, 0.1 mL of the test substance was instilled in the
conjunctival sac of six Vienna White rabbits. The eyes were not washed
after 24 hours of exposure. Animals were observed for 8 days. Irritation
was scored by the method of Draize et al..
The application to the intact eye resulted in marked redness in all
animals after 24 hours. The effect was not fully reversible, after 8
days three of 6 animals showed a slightly redness (grade 1) of the
conjunctivae. As the eyes were not washed out and the animals were only
observed for 8 days instead of 21 days as recommended in the current
OECD 405 guideline, it is reasonable to assume that effects would be
less pronounced and fully reversible if the eyes would have been washed
out and/or the observation period would have been extended to 21 days.
Slight to marked chemosis was observed in all animals, but was fully
reversible within 72 hours. After application, all animals showed a
slight corneal opacity, which was completely resolved by the end of the
study. The iris of two animals was affected by the test item after 24
hours, but this effect was fully reversible within 48 hours.
Based on these observations, the test article is not corrosive nor
irritant to the eye of rabbits based on Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again