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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
other: experimental data on similiar substance
Adequacy of study:
key study
Study period:
1979-10-22 to 1980-03-26
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Fed. Reg. 38, No. 187, § 1500.41 (Draize test)
Version / remarks:
1973
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Reaction mass of sodium [1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)][1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and sodium bis[1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and sodium bis[1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-)
IUPAC Name:
Reaction mass of sodium [1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)][1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and sodium bis[1-[(2-hydroxy-4-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-) and sodium bis[1-[(2-hydroxy-5-nitrophenyl)azo]-2-naphtholato(2-)]chromate(1-)

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
Mean body weight: males 3.16 kg, female 3.46 kg
The animals were offered a standardized animal laboratory diet.

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded skin
Vehicle:
water
Controls:
other: untreated skin of the animals
Amount / concentration applied:
about 0.5 g of a 50 % aqueous test substance preparation
Duration of treatment / exposure:
24 hours
Observation period:
8 days
Number of animals:
6 (5 males, 1 female)
Details on study design:
Application area: 2.5 x 2.5 cm
Application site: back
The test substance was not washed off.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h / 72 h
Score:
0
Max. score:
4
Remarks on result:
other: intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h / 72 h
Score:
0.75
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: abraded skin
Irritant / corrosive response data:
Due to substance-coloured skin, determination of the erythema score was not possible.

Applicant's summary and conclusion

Interpretation of results:
other: not classified under Regulation 1272/2008
Conclusions:
Not irritant to skin