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EC number: 217-316-1 | CAS number: 1809-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 20 to July 19, 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyl phosphonate
- EC Number:
- 217-316-1
- EC Name:
- Dibutyl phosphonate
- Cas Number:
- 1809-19-4
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- dibutyl phosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Housing: 40 L exposure chamber
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- - Air flow: 6.84 L/min
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 1 h
- Concentrations:
- Nominal 22.53 mg/L
- No. of animals per sex per dose:
- 10 laboratoty test rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- > 22.53 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- No mortality occurred
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according CLP Regulation (EC no. 1272/2008)
- Conclusions:
- LC0 (inhalation, rat, 1h) = 22.53 mg/L
- Executive summary:
The acute inhalation toxicity of the test item was evaluated in an experimental study performed in an equivalent manner to the OECD Guideline 433, Acute Inhalation Toxicity Fixed Concentration Procedure. 10 rats were exposed to the test item via a whole body air chamber with an air flow of 6.84L/minute for approximately one hour, in a limit test with a nominal concentration equivalent to 22.53 mg/L.
No mortality occurred during the study period. Mild erythema on ears, inactivity, salivation, nasal discharge during exposure was observed. The LC50 is therefore greater than 22.53 mg/L (nominal), and the LC0 is equal to 22.53 mg/L (nominal).
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