Registration Dossier
Registration Dossier
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EC number: 217-316-1 | CAS number: 1809-19-4
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- other: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Justification for Read Across is provided in Section 13 of IUCLID
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Environmental Health Criteria 65: Butanols – Four Isomers: 1-Butanol 2-Butanol tert-Butanol Isobutanol
- Author:
- Patty, F.A.
- Year:
- 1 982
- Bibliographic source:
- Industrial Hygiene and Toxicology, 3rd ed., New York, Chichester, Brisbane, Toronto, Singapore, Wiley-Interscience. IIC: 4571-4578.
- Reference Type:
- secondary source
- Title:
- n-Butyl Alcohol CAS N°: 71-36-3
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- OECD SIDS - ENEP Publication
Materials and methods
- Principles of method if other than guideline:
- Repeated applications to rabbits of 20 mL/kg bw/day for 30 days over a period of 6 weeks.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Source Chemical 09
- IUPAC Name:
- Source Chemical 09
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- 30 daily applications
Doses / concentrations
- Dose / conc.:
- 20 other: mL/kg bw/day
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Results of examinations
- Mortality:
- no mortality observed
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 other: mL/kg bw/day
- Based on:
- test mat.
- Sex:
- not specified
- Remarks on result:
- other: Mortality
- Remarks:
- No mortality observed during study period
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL (dermal, sub-acute, rabbit) = 20 mL/kg bw/day
- Executive summary:
The sub-chronic dermal toxicity of the substance was evaluated in an experimental study. Rabbits were exposed via the dermal route to 20 mL/kg bw/day of the test item for 30 days over a 6-week period.
No mortality or adverse signs of toxicity were recorded, therefore, the NOAEL was considered to be at least 20 mL/kg bw/day.
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