Registration Dossier
Registration Dossier
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EC number: 201-170-0 | CAS number: 79-03-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF-Test: 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The report describes findings after 1 and 24 hours and at the end of the observation period. For final evaluation, the findings after 48 and 72 hours from the raw data were taken into account.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propionyl chloride
- EC Number:
- 201-170-0
- EC Name:
- Propionyl chloride
- Cas Number:
- 79-03-8
- Molecular formula:
- C3H5ClO
- IUPAC Name:
- propanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): Propionsaurechlorid
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml - Duration of treatment / exposure:
- single application, no washing was performed
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
Results and discussion
In vivo
Results
- Irritation parameter:
- other: cauterization
- Basis:
- mean
- Time point:
- other: 1 h - 24 h - 8 d
- Reversibility:
- not reversible
- Remarks on result:
- other: scoring for chemosis, iris, conjunctivae and cornea not possible
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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