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EC number: 248-704-9 | CAS number: 27871-49-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the report attached in section 13 of IUCLID.
- Reason / purpose for cross-reference:
- read-across source
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 320 mg/L
- 95% CI:
- >= 305 - <= 417
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Observations on body length and weight:
no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Sublethal observations / clinical signs:
Table1: Measured concentrations of ethyl S(-) lactate.
Nominal concentration mg/L
Measured concentrations
t = 24 h
t = 48 h
mg/L
% of nominal
mg/L
% of nominal
0
<1
<1
100
80
80
50
50
180
154
86
120
67
320
276
86
222
69
Average % of nominal concentration
84
62
Average % of nominal during total test
73
Table 2: Number of surviving fishes at several concentrations of ethyl S(-) lactate and after several exposure times.
time (h)
Nominal concentration (mg/L)
0
100
180
320
560
1000
0
10
10
10
10
10
10
2
10
10
10
10
0
0
24
10
10
10
8
0
0
48
10
10
10
7
0
0
72
10
10
10
7
0
0
96
10
10
10
7
0
0
Table 3: Number of fishes and their condition at several concentrations of ethyl S(-) lactate and after several exposure times.
time (h)
Nominal concentration (mg/L)
0
100
180
320
560
1000
0
10a)
10a)
10a)
10a)
10a)
10a)
2
10
10
10
10
0
10d)
0
10d)
24
10a)
10b)
10b)
8
8b)
2d)
0
0
48
10a)
10b)
10b)
7
7b)
1d)
0
0
72
10a)
10b)
10b)
7b)
0
0
96
10a)
10b)
10b)
7b)
0
0
The following codes were used to denote condition:
a) Condition of all fisihes, visually assessed, normal (= good).
b) Condition of all fisihes, visualiy assessed, equal to that of the control fishes.
c) Number of slow swimming fishes.
d) Number of dead fishes.
- Executive summary:
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- C(=O)(C(C)O)OC
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 290 mg/L
- Remarks on result:
- other: calculated
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-h LC50 for methyl (S)-lactate in fish was estimated at 290 mg/L by QSAR modelling, indicating low acute toxicity to fish.
- Executive summary:
For the determination of the acute toxicity to fish, the 'Leadscope Enterprise model for acute toxicity to fathead minnow (96-h mortality, LC50)' as included in the Danish QSAR Database, has been applied. Based on the calculated 96-h LC50 value of 290 mg/L it can be concluded that methyl (S)-lactate shows low acute toxicity to fish, not fulfilling the CLP criterion for being classified as environmentally hazardous (≤100 mg/L).
Referenceopen allclose all
Description of key information
The 96-h LC50 value for methyl (S)-lactate in fish is predicted to be 290 mg/L by QSAR calculation.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- ca. 290 mg/L
Additional information
The predicted LC50 value of methyl (S)-lactate is 290 mg/L. This effect concentration matches well with the LC50 of 320 mg/L as determined for the read-across substance ethyl (S)-lactate. The good agreement of these two values indicates that the QSAR-calculated LC50 of 290 mg/L is conservative.
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