Registration Dossier
Registration Dossier
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EC number: 248-704-9 | CAS number: 27871-49-4
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-04-19 to 2010-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- May 31, 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Identification: PURASOLV@ ML
- Description: Clear colourless liquid
- Batch: 2010-03-22
- Purity: 99.03%
- Storage: At room temperature in the dark under nitrogen
- Expiry date: 2011-03-19 - Key result
- Melting / freezing pt.:
- < -90 °C
- Atm. press.:
- ca. 1 Bar
- Conclusions:
- The melting temperature of Methyl (S)-lactate is below -90 °C.
- Executive summary:
In a GLP study conducted according to OECD 102 and EU Method A.1, the melting temperature of Methyl (S)-lactate was determined by using DSC. Between -90 °C and 128 °C no endothermic effects were observed. The melting temperature of the test substance is below -90 °C.
Reference
Preliminary test
From 25 °C upwards the weight of the sample decreased significantly. At 128 °C the sample weight had decreased by 25%. After the experiment it was observed that the test substance was evaporated from the sample container.
Main study
The DSC-curve obtained with the first experiment is shown in the original study. No exothermic effects could be observed when the substance was cooled to -90 °C. When heated to 128 °C no endothermic effects could be seen which could attributed to the melting of the test substance. To investigate the possibility of crystallisation of the test substance below -90 °C, a sample pan was scratched at the inside in an attempt to better facilitate the initiation the crystallisation of the test substance. The DSC-curve which was obtained is provided in the original report. No exothermic effects could be observed.
Conclusion
The melting temperature of PURASOLV@ ML was determined by using DSC. No melting temperature could be observed above -90 °C.
Description of key information
The melting point of Methyl (S)-lactate is below -90 °C. No melting point was determined by using DSC between -90 °C to 128 °C in a GLP study conducted according to OECD 102.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -90 °C
Additional information
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