Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

Since the substance is not classified for mutagenicity and there is no evidence from an extended inhalation exposure study that the substance produces hyperplasia and/or pre-neoplastic lesions, the substance is currently considered non-carcinogenic.The substance does not need to be classified for carcinogenicity according the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.

Additional information

The test substance did not produce mutagenicity or genetic damage when tested in bacterial and mammalian cell cultures or in laboratory animals. Carcinogenicity via genetic mechanisms is not predicted. Additionally, no tissue damage or systemic effects were observed during repeated inhalation studies. Carcinogenicity by epigenetic mechanisms is not predicted. The lack of active genetic and epigenetic effects supports the position that carcinogenicity is not likely a concern with this test substance.