Registration Dossier
Registration Dossier
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EC number: 619-801-7 | CAS number: 66319-07-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- methyl 5-methyl-4-oxothiolane-3-carboxylate
- EC Number:
- 619-801-7
- Cas Number:
- 66319-07-1
- Molecular formula:
- C7H10O3S
- IUPAC Name:
- methyl 5-methyl-4-oxothiolane-3-carboxylate
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 5, 10 and 20% in DMSO
- No. of animals per dose:
- 4
Results and discussion
Any other information on results incl. tables
The proliferation index values were 4.4, 4.9% and 5% at treatment concentrations of 5%, 10% and 20% respectively.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item showed a potential for sensitization in this assay.
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