Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
other: ACUTE ORAL TOXICITY SCREENING IN THE RAT
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-anhydro-2,5-dideoxy-2-(methoxycarbonyl)-1-thiopent-3-ulose
EC Number:
619-801-7
Cas Number:
66319-07-1
Molecular formula:
C7H10O3S
IUPAC Name:
1,4-anhydro-2,5-dideoxy-2-(methoxycarbonyl)-1-thiopent-3-ulose

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: methylcellulose
Doses:
10 ml/kg
No. of animals per sex per dose:
3
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 300 mg/kg bw
Based on:
test mat.
Mortality:
At 300 mg/kg/body weight, no mortality were observed.
Clinical signs:
At 300 mg/kg/body weight, no clinical signs were observed.
Body weight:
The body weight of animals was unaffected by treatment.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for acute oral toxicity with the test item in the female rat was found to be more than 300 mg/kg body weight.