Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-anhydro-2,5-dideoxy-2-(methoxycarbonyl)-1-thiopent-3-ulose
EC Number:
619-801-7
Cas Number:
66319-07-1
Molecular formula:
C7H10O3S
IUPAC Name:
1,4-anhydro-2,5-dideoxy-2-(methoxycarbonyl)-1-thiopent-3-ulose

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
500µl
Duration of treatment / exposure:
4h
Observation period:
72h
Number of animals:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 1h
Score:
1
Max. score:
1
Reversibility:
no data
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24h
Score:
1
Max. score:
1
Reversibility:
no data
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 48h
Score:
1
Max. score:
1
Reversibility:
no data
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 72h
Score:
1
Max. score:
1
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 1h
Score:
0
Max. score:
0
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24h
Score:
0
Max. score:
0
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 48h
Score:
0
Max. score:
0
Reversibility:
no data
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 72h
Score:
0
Max. score:
0
Reversibility:
no data

Any other information on results incl. tables

There were no signs of systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test item was found to have a slight potential for dermal irritation in this study.