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EC number: 930-592-4
CAS number: -
Because the test substance is
characterized as UVCB substance and its composition is very complicated,
the literature search in toxicological databases was performed at first.
No toxicokinetic data about the
test substance were not found out.
Estimation of toxicokinetic
behaviour of the substance was performed mainly according
to experimental data from the experimental results obtained by the
The substance was applied to
laboratory animals (rat, mouse, and rabbit) during studies with
different way of entry into organism (e.g. stomach, skin and eye).
The test substance was not
absorbed from digestive tract after single administration of the test
substance. No clinical symptoms were found out. The test substance did
not penetrated through the skin of rabbit after single dermal
application on the skin of rat. No clinical signs of intoxication were
After single application of test
substance to the skin of rabbits, systemic toxic effects were not
detected – the substance obviously does not penetrate through the skin
after acute exposure. No irritation potential was found out after
application on ears of mice. The substance did not cause increase in
radioisotope incorporation into the DNA of dividing lymphocytes.
After single application of the
substance to conjunctival sac of the rabbit eye the local reversible
effects (redness, chemosis and lacrimation) appeared. These changes had
mild character. The substance was not irritating to the eye. Systemic
toxic effects were not detected - the test substance does not penetrate
to the body after acute eye exposure.
Reproduction/Developmental study in rats revealed that the test
substance had negative influence on reproduction parameters of parental
females - decreased number of corpora lutea, implantations with effect
on litter data - decreased number of pups and weight of litters was
recorded. There was no evidence that the substance could get through
placenta and affect the embryo or fetus. Development of pups was
No information was found about
absorption and excretion of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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