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Reaction product of Crude sludge and Calcium oxide. Crude sludge is the mixture of by-products of petroleum hydrocarbons refining (especially Total petroleum hydrocarbons, Polycyclic aromatic hydrocarbons, acid-refined heavy petroleum distillates). The Crude sludge is neutralised by calcium oxide in the ratio 80:20. The maturing process proceeds under ambient conditions and takes for at least 3 days. Subsequently, the reaction product is processed mechanically.
EC number: 930-592-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The test substance, Reaction product of Distillates (petroleum), acid-treated heavy naphthenic and calcium oxide, was tested for subchronic toxicity using the Method B.26 Sub-Chronic Oral Toxicity Test: Repeated Dose 90-day Oral Toxicity Study in Rodents, Council Regulation (EC) No. 440/2008, Published in O.J. L142, 2008.
No other studies on repeated dose toxicity (dermal or inhalation) of the substance are available.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 160 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The repeated dose oral toxicity 90-day study in Wistar rats of SPF quality was performed.
The test substance was administered in olive oil by stomach tube, oral application of rats was made daily. Four main groups and two satellite groups of animals were used. Main groups contained 3 treated groups (doses 160, 400, 1000 mg/kg of body weight /day) and one control group (vehicle only). The satellite groups contained one control group (vehicle only) and one treated group (1000 mg/kg/day).
The value of NOAEL (No Observed Adverse Effect Level) was established 160 mg/kg/day. The value was established mainly on the basis of changes in red blood cell component, biochemical parameters related to kidney function and histopathology of the liver.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver; urogenital: kidneys
Justification for classification or non-classification
According to the Regulation (EC) No.1272/2008 the data from the study „Reaction product of Distillates (petroleum), acid-treated heavy naphthenic and calcium oxide - Repeated Dose 90-day Oral Toxicity Study“ (Study No. 49/10/8, VUOS Report No.11-46, 2011) are of acceptable quality for classification or non-classification of substances for STOT RE (Specific Target Organ Toxicity – Repeated Exposure).
The determined value of NOAEL (160 mg/kg body weight/day) was used for comparison with classification criteria.
In accordance with guidance values for STOT RE (Guidance to Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of substances and mixtures) the value (dose/concentration) for STOT RE Category 1 is C ≤ 10 mg/kg body weight/day, the range (dose/concentration) for STOT RE Category 2 is 10 < C ≤ 100 mg/kg body weight/day for oral route exposure.
The value of NOAEL (160 mg/kg body weight/day) is above the guidance values and range (C).
Based on results of Repeated Dose 90-day Oral Toxicity Study, the substance „Reaction product of Distillates (petroleum), acid-treated heavy naphthenic and calcium oxide“ is not classified as specific target organ toxicant - repeated exposure.
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