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EC number: 270-335-7 | CAS number: 68425-15-0
Table 1 : pregnancy status
Number of mated females
. found dead
Alive at terra
. total resorption
In an OECD TG 414 study, three groups of 25 mated female rats received di-tert-dodecyl polysulfides (TPS 32), by oral gavage at the dose levels of 50, 250 or 1000 mg/kg/day, each day from day 6 to day 15 post-coitum inclusive. Simultaneously, a group of 25 mated females was given the vehicle alone (0.5% carboxymethylcellulose) under the same conditions and acted as a control group.Clinical signs including (including evidence of abortion/resorption) and mortality were checked daily. Food consumption and body weight were recorded at designated intervals during pregnancy. On day 20 post-coitum, females were killed. The gravid uterus was weighed and fetuses were removed by hysterectomy. Females were examined macroscopically. Litter parameters were recorded: number of corpora lutea, implantation sites, resorptions, dead and live fetuses. The live fetuses were weighed, sexed, submitted to an external examination and then to soft tissue or skeletal examinations.
No clinical signs and no unscheduled deaths were observed in any group. No females aborted or presented total resorption in any group. The food consumption and body weight gain of the pregnant females from all treated groups were similar to those of controls. No treatment-related macroscopic findings were observed, in any group.
The post-implantation loss was similar in the 0, 50 and 250 mg/kg/day groups. In the 1000 mg/kg/day group, a slightly increased post-implantation loss (represented mainly by late resorptions, observed in one female) was observed: it could not be demonstrated that this single event was treatment-related. No treatment-related effects were observed on the number of live fetuses per animal, the fetal body weight or the sex-ratio.No treatment-related external, soft tissue and skeletal anomalies or malformations were observed in any group.
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