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Registration Dossier
Diss Factsheets
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EC number: 270-335-7 | CAS number: 68425-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Experimental results are available for fish, Daphnia, algae and microorganisms. Key studies chosen for these endpoints are included in this dossier. The following sections detail the robust summaries prepared for these studies.
Thiebaud (2000) is a GLP-compliant guideline study showing the growth inhibition effect of polysulfides, di-tert-dodecyl on Pseudokirchneriella subcapita over 72 hours. The maximum level of exposure, the observed saturation concentration (0.080 mg/L), resulted in no inhibition of the growth of Pseudokirchneriella subcapita. The study is considered reliable and suitable for use for this endpoint.
Thiebaud (1998) is a 48 hour, static, freshwater, GLP-compliant test on Daphnia magna, follows EU Method C2. The results indicate that this substance is not significantly acutely toxic to aquatic invertebrates at the limit of analytical detection and the limit of dispersibility. The validity criteria of the method were not met as the stability of the substance was not checked. The study is considered reliable with restriction and suitable for use for this endpoint.
Hoffmann (2010) is a GLP-compliant, static closed vessel limit test following OECD guideline 203. No further dose-response test was performed despite the limit test showing some toxic effects. Careful examination of WAF preparation shows that the absence of undissolved material cannot be no guaranteed. The study has consequently been classified as not reliable. No further information would have been gained about the toxicity of the test item from further acute dose-response testing. Further data on the poor water solubility of the substance justified that no further acute testing was warranted. Instead, chronic toxicity could be considered.
It has been hypothetized that, in view of the predicted very low water solubility and the prediction of ecotoxicity made using ECOSAR models (from USEPA's EPIWIN suite) for algae, daphnia and fish, acute and chronic on substance Polysulfides, di-tert-dodecyl, the resulting EC50s and chronic values are all higher than the limit of solubility.
Consequently, the aquatic chronic fish and invertebrate tests were waived but, according to REACH annexes, these two studies were requested by ECHA. These studies (OECD TG 210 and 211) have now been carried out and they confirm that no long term toxic effect is observed on fish (Pimephales promelas) and lotic invertebrate (Daphnia magna) at water solubility saturation level. Indeed, water solubility has been confirmed to be 0.00026 mg/L and in the two toxicity assays the exposure levels were managed to be slightly higher than saturation (0.00079 - 0.00084 mg/L).
This means that no PNEC can be derived for aquatic media (freshwater, marine water, including intermittent releases).
Besides, investigations of fate and eventually effects in sediments which is the likely target compartment given the properties of this substance have been proposed. An OECD TG 218 has been carried out and the results are reported in the adequate section.
The results of the available studies, including the recent chronic aquatic toxicity studies support that the substance polysulfides, di-tert-dodecyl, does not need to be classified concerning hazard to the environment, according to CLP regulation rules relevant to the "safety net" classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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