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EC number: 431-840-1 | CAS number: 87010-29-5 OXIPROPAZON; OXYPROPAZON
Endpoint summary
Administrative data
Description of key information
- skin irritation: negative (OECD guideline 404)
- eye irritation: negative (OECD guideline 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
Oxypropazone was investigated for primary irritant/corrosive effects at the skin of rabbits according to OECD guideline 404 and GLP (ASTA Medica, 1991). 0.5 mL of the test substance was given to the dorsal skin area of three rabbits each (4 hours, occlusive patch).
During the observation period neither erythema nor edenm could be detected. The primary irritatin indes was 0. Since also no systemic toxicity has been observed, the test item can be classified as non-irritating.
Eye Irritation:
The eye irritating potential of Oxypropazone was investigated according to OECD guideline 405 and GLP (ASTA Medica, 1991). 0.1 ml of the test substance was applied to the right eye (conjunctival sac) of three individual rabbits. Eyes were not rinsed following application. The Conjuctiva, iris and cornea were observed 1, 24, 48 and 72 h following substance application and scored based on the Draize scoring system. The following eye lsions have been observed:
Cornea: Diffuse areas of opacity (one rabbit)
Irsi: Moderate circumcorneal hyperemia (one animal)
Conjunctiva: Hyperemia, diffuse beefy redness of all sections, slight swelling, obvious swelling with partial eversion of lids
Additional lesions: Slight dischargem discharge wth moistening of considerable areas around the eye
The mean scores for all three animals for 24, 48 and 72 h were as follows:
Cornea: 0,22
Iris: 0,22
Conjunctiva redness: 0,89
Conjunctiva Chemosis: 0,625
In two arbbits, the effects diminished follwing three days; in the third rabbit, lesions were reversible within 6 days. The primary irritation score according to Gilman et al was 8. Furthermore, no systemic toxicity has been observed in the rabbits. Taken together, these data show that the test item is not irritating to eyes.
Justification for classification or non-classification
Based on the results of the skin and eye irritation study, the substance does not need to be classified according to Directive 67/548/EEC and according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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