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Diss Factsheets
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EC number: 463-070-5 | CAS number: 106966-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Adequacy of study:
- other information
- Study period:
- November 2008
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Experimental data, literary data obtained from internet, data obtained from commercial toxicological databases and from Scientific and Tehnical
Information Network.
Test material
- Reference substance name:
- -
- EC Number:
- 463-070-5
- EC Name:
- -
- Cas Number:
- 106966-25-0
- Molecular formula:
- C7H17N2O2Br
- IUPAC Name:
- 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethylhydrazinium bromide
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Because no relevant toxicokinetic literary references were found, about behaviour of the test substance in organism of experimental animals was presumed only from results of toxicological testing, which was performed previously. The test substance applied to experimental animals (rat, rabbit, guinea pig) during studies with different way of entry (eye, oral or intradermal) into organism after single application, invoke the toxic answer of organism: death of animals, clinical and pathological findings. The test substance may be considered as substance, which very rapidly penetrated into organism after single application of high dose level - death or clinical toxicological symptoms occurred very soon after application. Absorption and distribution of the test substance in organism was recorded after repeated per-oral application to experimental animals. Long-term application had lethal effect only in one pregnant female (dose level 120 mg/kg/day). The test substance probably influenced digestion of animals (diarrhoea or watery excrements) but without negative effect on growth of animals. After absorption from the digestive system the test substance is probably distributed into nervous system (apathy, decreased activity)and urogenital system (changes in metabolism of water and ions and decreased fertility of males and females). In pregnant females the test substance influenced development of organism in uterus. Absorption of the test substance through skin was not confirmed according to the results of Acute toxicity: Dermal Irritation / Corrosion. According to the results of Inhalation study it is not possible to confirm absorption of the test substance from respiration system.
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