Registration Dossier
Registration Dossier
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EC number: 463-070-5 | CAS number: 106966-25-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.10.-22.11.2007.
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for test
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 463-070-5
- EC Name:
- -
- Cas Number:
- 106966-25-0
- Molecular formula:
- C7H17N2O2Br
- IUPAC Name:
- 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethylhydrazinium bromide
Constituent 1
Sampling and analysis
- Details on sampling:
- Samples for analytical determination were taken at the beginning, after 24 hours and at the end of the test. The results showed that
concentrations at the beginning of the test decreased to the end of the test for 30.3-51.3%.
Therefore for the calculation EC and NOEC values the average exposure concentrations were used. Average exposure concentrations were
calculated as geometric mean of the concentrations measured at the start, after 24 hours and at the end of the test.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Desmodesmus subspicatus
- Strain: from the collection of autotrophic organisms of The Botanic Institute of the Czech Academy of Science
- Source: culture collection
ACCLIMATION
- Acclimation period: 3 days
- Culturing media and conditions (same as test or not): same as test
- Any deformed or abnormal cells observed: no
Study design
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23 ± 2 degree of Celsius
- Nominal and measured concentrations:
- Initial concentration of algae culture: 10000 cells in a 1 mL
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 172 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- other: growth and biomass
- Remarks on result:
- other: 30.3-51.3%
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 128 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- other: growth and biomass
- Remarks on result:
- other: 30.3-51.3%
Applicant's summary and conclusion
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