Registration Dossier
Registration Dossier
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EC number: 439-840-1 | CAS number: 20846-91-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In a GLP study conducted according to OECD Guideline 203, trisodium EDDS was not acutely toxic to the freshwater fish, Brachydanio rerio, when tested up to a nominal concentration of 1000 mg/L, therefore the 96-h NOEC value for survival and condition was 1000 mg/L.
Key value for chemical safety assessment
Additional information
A GLP study conducted according to OECD Guideline 203 was performed to determine the acute toxicity of trisodium EDDS to Brachydanio rerio (10 fish/concentration). The test was carried out under semi-static conditions with daily replacement of the test solutions. Fish were exposed to trisodium EDDS in freshwater at nominal concentrations of 0, 100, 180, 320, 560 and 1000 mg/L and observed for survival, condition (swimming behaviour, colour, respiratory function or any other visually observable morphological or behavioural criterion) of the survivors after 24, 48, 72 and 96 h of exposure. After 96 h, all animals were alive and their condition was comparable to that of the control animals. All test solutions were completely clear (visually assessed) throughout the test. In conclusion, the 96-h NOEC for survival and condition of freshwater fish was 1000 mg/L (the highest tested nominal concentration), and the 96-h LC50 would be >1000 mg/L (Hooftman and van Drongelen-Sevenhuijsen, 1993).
No data in marine fish are currently available for EDDS acid or its trisodium salt.
[Data on trisodium EDDS is considered relevant to use for understanding the potential toxicity to fish of EDDS acid, and is acceptable for using as read-across information].
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