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EC number: 700-330-1 | CAS number: 433733-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 2010 - Marc 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Fish bioconcentration test in carp with Anhydrothymidine
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline No. 305, 1996
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EC) No 440/2008, Part C.13, 2008
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- During the bioconcentration test, samples were taken from the test medium and from the fish for
several purposes and at several timepoints:
Analysis of medium: 24 samples
Analysis of fish: 60 fish
Fish lipid extraction: 16 fish
Uptake phase Frequency No. of water samples No. of fish per conc.
(days) control low high control low high
Check -1 1 1 1 - - -
Start 0 1 1 1 - - -
1st 1 1 1 1 2 4 4
2nd 3 1 1 1 2 4 4
3rd 7 1 1 1 2 4 4
4th 14 1 1 1 2 4 4
5th 21 1 1 1 2 4 4
6th - Vehicle:
- yes
- Remarks:
- adjusted ISO-medium
- Details on test solutions:
- Adjusted ISO medium, formulated using RO-water (tapwater purified by reverse osmosis; GEON Waterbehandeling, Berkel-Enschot, The Netherlands) with the following composition:
CaCl2.2H2O 211.5 mg/l
MgSO4.7H2O 88.8 mg/l
NaHCO3 46.7 mg/l
KCl 4.2 mg/l - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Source Zodiac, proefacc, “De Haar Vissen”, Wageningen University and Research Centre, The Netherlands
Initial fish length 5.4 ± 0.3 cm, based on measurement of all fish used for this test
Initial fish weight 4.53 ± 0.62 g, based on weighing of all fish used for this test
Characteristics F1 from a single parent-pair bred in UV-treated water. - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
- Hardness:
- 179 mg calcium carbonate per litre
- Test temperature:
- 20-25°C
- pH:
- 7.1 to 8.0
- Dissolved oxygen:
- 7.0 to 9.3 mg/l
- Nominal and measured concentrations:
- Time of measurement measured Anhydrothymidine concentration (mg/l)
(days) Target concentration Target concentration
0.10 mg/l 1.0 mg/l
Actual Actual
0 0.102 0.96
1 0.102 0.95
3 0.103 0.95
7 0.095 1.03
14 0.110 1.06
21 0.104 1.15
28 0.095 0.93 - Details on test conditions:
- Analyses showed that the actual concentrations were in agreement with the target concentrations (93-
115%). The mean concentrations of Anhydrothymidine were 0.10 ± 0.0052 mg/l and 1.0 ± 0.081 mg/l
at target concentrations of 0.10 and 1.0 mg/l, respectively. The measured concentrations varied within
the ± 20% window of the mean concentration at both target concentrations. - Reference substance (positive control):
- no
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: BCF
- Effect conc.:
- 0.066 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: bioconcentration
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: BCF
- Effect conc.:
- 0.053 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: bioconcentration
- Validity criteria fulfilled:
- yes
- Conclusions:
- The bioconcentration study investigated the possible bioconcentration of Anhydrothymidine in carp exposed to two different concentrations for a period of 28 days in a flow through system.
The mean BCF-values of Anhydrothymidine at target concentrations of 0.10 and 1.0 mg/l were 0.066 ± 0.036 and 0.053 ± 0.026, respectively. Therefore, the uptake of Anhydrothymidine by fish proved to be insignificant.
Hence there is no substantial risk for bioconcentration of Anhydrothymidine in fish.
Reference
Description of key information
The bioconcentration study investigated the possible bioconcentration of Anhydrothymidine in carp exposed to two different concentrations for a period of 28 days in a flow through system.
The mean BCF-values of Anhydrothymidine at target concentrations of 0.10 and 1.0 mg/l were 0.066 ± 0.036 and 0.053 ± 0.026, respectively. Therefore, the uptake of Anhydrothymidine by fish proved to be insignificant.
Hence there is no substantial risk for bioconcentration of Anhydrothymidine in fish.
Key value for chemical safety assessment
Additional information
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