Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 15 2020 - October 15 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Not specified
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 0.3
- Temp.:
- 25 °C
- pH:
- 7
- Details on results:
- The log Pow values oftest item components were considered to be less than 0.3 because the retention times of start and end of peak were shorter than that of the reference substance 2-butanone (log Pow= 0.3).
- Conclusions:
- The log Pow values of test item components were considered to be less than 0.3 because the retention times of start and end of peak were shorter than that of the reference substance 2-butanone (log Pow= 0.3).
- Executive summary:
The objective of this study was to obtain the 1-octanol/water partition coefficient of Dye-2019. The study was carried out in accordance with OECD test guideline 117 – Partition coefficient (0-octanol/water), High Performance Liquid Chromatography (HPLC) method, in compliance with GLP.
The partition coefficient of test item could not be measured in an undissociated form because the test item has sulfonic acid groups. Therefore, this test was performed using the buffer solution of pH7.0 as an eluent. In a preliminary test, the retention times of test item components were shorter than that of 2-butanone (reference item, log Pow=0.3). Therefore, the retention times of test item components were compared with that of 2-butanone and then the log Pow values of test item components were evaluated in this test. The partition coefficient of the test item was determined to be <0.3 (pH7.0 at 25°C)
Reference
The retention times and the partition coefficients oftest item and reference item at 25 °C are shown as follows:
Name |
Retention time [peak range] (min) |
Log Pow |
Reference item – 2-butanone |
4.09 |
0.3 |
4.08 |
0.3 |
|
Test item |
1.54 [1.39-3.21] |
<0.3 |
1.54 [1.39-3.21] |
<0.3 |
Description of key information
The partition coefficient of the test item was determined to be <0.3 (pH7.0 at 25°C)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.3
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
